Population
Human myocardium (normal and affected by dilated cardiomyopathy) and aorta
Comparison
Isolation and analysis of tissue-specific antigens vs Normal human myocardium
Design
Preclinical
Authors
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Should not yet change DCM management; hypothesis-generating for contractile protein roles and requires human validation.
Demonstrates a significant reduction in key structural proteins (actin, myosin, tropomyosin) in human myocardium affected by dilated cardiomyopathy.
Bobik et al. (1993) studied this question.
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