May 29, 2008International Journal of Epidemiology

Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations

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Why the study?

Does the NOS1AP SNP rs10494366 minor allele (G) prolong the QTc interval differently in men and women?

Structured PICO

Does the NOS1AP SNP rs10494366 minor allele (G) prolong the QTc interval differently in men and women?

Population

3761 individuals from two independent populations: 919 women and 918 men from 504 representative families in the UK GRAPHIC study, and 699 women and 1225 men referred for exercise testing in the Finnish FINCAVAS study

Intervention

NOS1AP SNP rs10494366 minor allele (G)

Comparator

Major allele / non-carriers

Outcome

Heart-rate corrected QT interval (QTc) at rest and at 3 min recovery after exercisesurrogate

A common genetic variant in NOS1AP (rs10494366) is associated with prolonged QTc intervals, with a significantly greater effect observed in women at rest.

Discussion

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Implication

Greater QTc prolongation by rs10494366 in women; hypothesis-generating for sex-specific arrhythmia risk and requires replication.

Cite This Study

Tobin et al. (2008) studied this question.

synapsesocial.com/papers/6a8491d8c7e37ebe3168e7db https://doi.org/10.1093/ije/dyn091

View Full Paper

Ask AI

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Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations

Structured PICO

Discussion

Implication

Cite This Study

Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider