November 25, 2003Journal of VirologyOpen Access

The δ Region of Outer-Capsid Proteinμ1 Undergoes Conformational Change and Release from ReovirusParticles during CellEntry

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Population

Reovirus particles (ISVPs, ISVP*, core particles) and cells in culture / erythrocytes

Comparison

Antibody reagents and recoated particles with… vs Native ISVPs and recoated particles with…

Design

Preclinical

Authors

KCKarthic ChandranUniversity of South Florida JPJohn S. L. ParkerCornell University MEMarcelo EhrlichTel Aviv University

Discussion

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Implication

Advances reovirus entry models in animals; leaves open human therapeutic implications for oncolytic virotherapy.

Structured PICO

Population

Reovirus particles (ISVPs, ISVP*, core particles) and cells in culture / erythrocytes

Intervention

Antibody reagents (monoclonal antibodies for delta region of mu1, antiserum against cores, antibodies for sigma1) and recoated particles with hyperstable mutant mu1

Comparator

Native ISVPs and recoated particles with wild-type proteins

Outcome

Conformational changes in mu1, release of delta fragment, and subcellular localization during cell entry

The study elucidates the structural changes and disassembly steps of reovirus particles during cell entry, identifying ISVP* as a key transient intermediate for membrane penetration.

Cite This Study

Chandran et al. (2003) studied this question.

synapsesocial.com/papers/6a84922a2327ba91ab8d99bb https://doi.org/10.1128/jvi.77.24.13361-13375.2003

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The δ Region of Outer-Capsid Proteinμ1 Undergoes Conformational Change and Release from ReovirusParticles during CellEntry

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The δ Region of Outer-Capsid Proteinμ1 Undergoes Conformational Change and Release from ReovirusParticles during CellEntry

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider