Like drug resistance in microbes, the evolution of insecticide resistance by insects threatens human welfare through its impact on crop protection and disease transmission. The introduction of new insecticides has resulted in a rapid increase in resistance (see the figure), with many species now resisting several classes of insecticide. Predicting and managing resistance requires information on cross-resistance characteristics and on the origins, selection, and spread of resistance genes. On page 2253 of this issue, Daborn et al. address these aspects and extend the number of mechanisms for which detailed information about their molecular and population genetics is now available (1).
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Denholm et al. (2002) studied this question.
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