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April 28, 1967Science

Human Polymorphonuclear Leukocytes: Demonstration of Microtubules and Effect of Colchicine

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Authors

SMStephen E. MalawistaYale UniversityKBKlaus G. BenschStanford University

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Implication

Laboratory study reveals microtubule disassembly by colchicine in human polymorphonuclear leukocytes, indicating preserved phagocytic capacity despite structural disruption.

Key Points

  • Investigate the presence of microtubules in mature human polymorphonuclear leukocytes and determine how colchicine affects their cellular structure and phagocytic function.
  • Maintained mature human polymorphonuclear leukocytes under extended in vitro incubation conditions.
  • Treated leukocyte preparations with colchicine to observe structural alterations and assess functional phagocytosis.
  • Microtubules remained detectable in mature human polymorphonuclear leukocytes even following prolonged in vitro incubation.
  • Colchicine treatment eliminated visible microtubules and altered leukocyte function, yet did not inhibit phagocytosis.

Cite This Study

Malawista et al. (1967) studied this question.

synapsesocial.com/papers/6a849a339c80cd55e4387c8ahttps://doi.org/10.1126/science.156.3774.521
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Also Consider

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  1. 1ORIGIN OF GRANULES IN POLYMORPHONUCLEAR LEUKOCYTES1966 · 475 citations
  2. 2SOME STRUCTURAL AND FUNCTIONAL ASPECTS OF THE MITOTIC APPARATUS IN SEA URCHIN EMBRYOS1962 · 188 citations
  3. 3Suppression of metabolic accompaniments of phagocytosis by colchicine1965 · 57 citations
  4. 4STUDIES ON THE MICROTUBULES IN HELIOZOA1966 · 206 citations