Central infusion of IL-1beta increases blood pressure via stimulation of AT1 receptors in the paraventricular nucleus in a rat model.
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Central IL-1β raises BP via AT1 receptors in rats; extends mechanistic insights but leaves open human hypertension relevance.
OBJECTIVE: To investigate the possible participation of angiotensin II receptor 1 (AT(1) receptor) in pressor response induced by IL-1beta in the paraventricular nucleus (PVN) of hypothalamus. METHODS: The experiments were performed on adult Wistar rats. Mean arterial pressure (MAP) were recorded during microinjection of different doses of IL-1beta, IL-1beta together with Losartan, an AT1 receptor antagonist, or Ang II pre-treated with IL-1beta into PVN. Rats microinjected with saline were served as controls in all experiments. RESULTS: Microinjection of IL-1beta (0.1 or 0.2 ng) resulted in increases in blood pressure in a dose-dependent manner, and the pressor effect caused by administration of IL-1beta (0.2 ng) could be attenuated by pre-treatment with AT(1) receptor antagonist (100 ng Losartan). A subpressor dose of IL-1beta (0.05 ng) could augment the pressor response induced by microinjection of Ang II (10 ng). DISCUSSION: The present results provide support that central infusion of IL-1beta increases blood pressure and the pressor response requires stimulation of AT(1) receptors. It is also shown that IL-1beta has the effect of increasing the magnitude of pressor response induced by Ang II in PVN.
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Yang et al. (2008) studied this question.
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