What does this research mean for the field?

Excitatory synaptic inputs to pressor neurons in the rostral ventrolateral medulla arising from activation of the hypothalamic paraventricular nucleus are predominantly mediated by AT1 receptors. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1999Hypertension

AT1Receptors Mediate Excitatory Inputs to Rostral Ventrolateral Medulla Pressor Neurons From Hypothalamus

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Population

Anesthetized rats

Comparison

Microinjections of specific AT1 receptor… vs Contralateral microinjections, or…

Design

Preclinical

Authors

TTTatsuya TagawaFukuoka International University RDR.A.L. DampneyGeneral Cardiology

Discussion

Member takes

Implication

Supports AT1 mediation of central sympathoexcitation in animals; leaves open translation to human hypertension therapies.

Structured PICO

Population

Anesthetized rats

Intervention

Microinjections of specific AT1 receptor antagonists (losartan or L-158,809) into the rostral ventrolateral medulla

Comparator

Contralateral microinjections, or microinjections of muscimol or kynurenic acid

Outcome

Pressor and sympathoexcitatory responses evoked by paraventricular nucleus activationsurrogate

Excitatory synaptic inputs to pressor neurons in the rostral ventrolateral medulla arising from activation of the paraventricular nucleus are mediated predominantly by AT1 receptors.

Cite This Study

Tagawa et al. (1999) studied this question.

synapsesocial.com/papers/6a1e860940bc8a3dd76903e5 https://doi.org/10.1161/01.hyp.34.6.1301

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AT1Receptors Mediate Excitatory Inputs to Rostral Ventrolateral Medulla Pressor Neurons From Hypothalamus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

AT1Receptors Mediate Excitatory Inputs to Rostral Ventrolateral Medulla Pressor Neurons From Hypothalamus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider