September 1, 1996Clinical and Experimental Pharmacology and Physiology

Proceedings of the Symposium ‘Angiotensin AT1 Receptors: From Molecular Physiology to Therapeutics’: ROLE OF AT1 RECEPTORS IN THE CENTRAL CONTROL OF SYMPATHETIC VASOMOTOR FUNCTION

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Why the study?

Does central administration of Angiotensin II and AT1 antagonists modulate sympathetic vasomotor function in rabbits?

Population

Conscious and anaesthetized rabbits

Design

Review

Authors

GHGeoffrey A. HeadPreventive Cardiology

Discussion

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Implication

Brainstem AT1 receptors modulate sympathetic vasomotor reflexes in rabbits; leaves open translation to human hypertension therapies.

Structured PICO

Does central administration of Angiotensin II and AT1 antagonists modulate sympathetic vasomotor function in rabbits?

Population

Conscious and anaesthetized rabbits

Intervention

Central administration of Angiotensin II (AngII) and AT1 receptor antagonists (e.g., losartan) into the fourth ventricle or rostral ventrolateral medulla

Outcome

Haemodynamic changes, blood pressure, and sympathetic vasomotor reflexes (e.g., renal sympathetic nerve activity)surrogate

Angiotensin AT1 receptors in the brainstem play a key role in modulating sympathetic vasomotor reflexes and integrating autonomic response patterns in rabbits.

Cite This Study

Geoffrey A. Head (1996) studied this question.

synapsesocial.com/papers/6a7c905f3dbea9de81610ea4 https://doi.org/10.1111/j.1440-1681.1996.tb02820.x

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Proceedings of the Symposium ‘Angiotensin AT1 Receptors: From Molecular Physiology to Therapeutics’: ROLE OF AT1 RECEPTORS IN THE CENTRAL CONTROL OF SYMPATHETIC VASOMOTOR FUNCTION

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Proceedings of the Symposium ‘Angiotensin AT1 Receptors: From Molecular Physiology to Therapeutics’: ROLE OF AT1 RECEPTORS IN THE CENTRAL CONTROL OF SYMPATHETIC VASOMOTOR FUNCTION

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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