What question did this study set out to answer?

To evaluate the physiological role of brainstem angiotensin II and AT1 receptors in modulating baroreflex control of renal and cardiac autonomic pathways.

September 1, 2002Brazilian Journal of Medical and Biological ResearchOpen Access

Angiotensin and baroreflex control of the circulation

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Population

Conscious and anesthetized rabbit models

Design

Review

Authors

GHGeoffrey A. HeadPreventive Cardiology TSTakeshi SaigusaUniversity of Yamanashi DMDmitry N. MayorovThe University of Melbourne

Discussion

Member takes

Implication

Brainstem Ang II modulation may inform stress-related autonomic responses; leaves open clinical translation pending human interventional data.

Key Points

To evaluate the physiological role of brainstem angiotensin II and AT1 receptors in modulating baroreflex control of renal and cardiac autonomic pathways.
Reviewed experimental models administering angiotensin II, sarile, or losartan via the fourth ventricle or directly into the rostral ventrolateral medulla.
Evaluated acute and chronic cardiovascular and renal sympathetic nerve activity baroreflex responses in conscious and anesthetized rabbits.
Fourth-ventricle or rostral ventrolateral medulla activation of AT1 receptors acutely increased renal sympathetic nerve activity and enhanced sympathetic baroreflex responses.
Fourth-ventricle losartan administration produced sympathoexcitation in conscious rabbits but markedly attenuated renal sympathetic nerve responses to acute airjet stress.
Chronic fourth-ventricle angiotensin II infusion inhibited heart rate baroreflex sensitivity, whereas chronic losartan administration significantly increased baroreflex gain.

Structured PICO

Population

Conscious and anesthetized rabbit models

Intervention

Central administration of Angiotensin II, Sarile, or Losartan (fourth ventricle or rostral ventrolateral medulla)

Outcome

Renal sympathetic nerve activity (RSNA) and baroreflex responsessurrogate

This review highlights the physiological role of brainstem Angiotensin II in modulating baroreflex control and integrating autonomic responses during stress.

Cite This Study

Head et al. (2002) studied this question.

synapsesocial.com/papers/6a7162b1febe604dd70a0da5 https://doi.org/10.1590/s0100-879x2002000900005

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Implication

Brainstem Ang II modulation may inform stress-related autonomic responses; leaves open clinical translation pending human interventional data.

Angiotensin and baroreflex control of the circulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Angiotensin and baroreflex control of the circulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider