What question did this study set out to answer?

To describe how interconnected signaling networks coordinate cell motility, directional sensing, and cell polarity during eukaryotic chemotaxis.

April 1, 2010Annual Review of BiophysicsOpen Access

Eukaryotic Chemotaxis: A Network of Signaling Pathways Controls Motility, Directional Sensing, and Polarity

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Authors

KSKristen F. SwaneyJohns Hopkins University CHChuan‐Hsiang HuangJohns Hopkins University PDPeter N. DevreotesJohns Hopkins University

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Implication

Narrative review reveals signaling networks governing cell motility, directional sensing, and polarity in Dictyostelium, highlighting universal mechanisms of eukaryotic chemotaxis.

Key Points

To describe how interconnected signaling networks coordinate cell motility, directional sensing, and cell polarity during eukaryotic chemotaxis.
Reviewed genetic and biochemical investigations utilizing the model organism Dictyostelium.
Analyzed the molecular interactions coordinating pseudopod formation, spatial gradient perception, and asymmetric protein segregation.
Motility functions via spontaneous actin waves propagating through the cytoskeleton to drive random pseudopod extensions.
Directional sensing mechanisms detect spatial and temporal chemical stimuli to bias cell movements toward concentration gradients.
Cell polarity is established by selectively compartmentalizing signaling proteins and activities to distinct leading and lagging edges.

Cite This Study

Swaney et al. (2010) studied this question.

synapsesocial.com/papers/6a849be0c3be978f8d8d9b89 https://doi.org/10.1146/annurev.biophys.093008.131228

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Implication

Narrative review reveals signaling networks governing cell motility, directional sensing, and polarity in Dictyostelium, highlighting universal mechanisms of eukaryotic chemotaxis.

Eukaryotic Chemotaxis: A Network of Signaling Pathways Controls Motility, Directional Sensing, and Polarity

Discussion

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Implication

Key Points

Cite This Study

Eukaryotic Chemotaxis: A Network of Signaling Pathways Controls Motility, Directional Sensing, and Polarity

Discussion

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Implication

Key Points

Cite This Study

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