May 3, 1999The Journal of Cell BiologyOpen Access

UNC-60B, an ADF/Cofilin Family Protein, Is Required for Proper Assembly of Actin into Myofibrils in Caenorhabditis elegans Body Wall Muscle

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Population

Caenorhabditis elegans (wild-type and unc-60 mutants)

Comparison

unc-60 mutations vs Wild-type UNC-60B

Design

Preclinical

Authors

SOShoichiro OnoHeart Failure & Transplant DBDavid L. BaillieThe Dodd-Walls Centre for Photonic and Quantum Technologies GBGuy M. BenianEmory University

Discussion

Member takes

Implication

Does not inform clinical practice; leaves open whether cofilin homologs regulate myofibril assembly in mammals.

Structured PICO

Population

Caenorhabditis elegans (wild-type and unc-60 mutants)

Intervention

unc-60 mutations (specifically in the UNC-60B coding region)

Comparator

Wild-type UNC-60B

Outcome

Assembly of actin into myofibrils and F-actin binding, depolymerizing, and severing activitiessurrogate

Precise control of actin filament dynamics by the ADF/cofilin family protein UNC-60B is required for proper integration of actin into myofibrils in C. elegans.

Cite This Study

Ono et al. (1999) studied this question.

synapsesocial.com/papers/6a849be5e9b2b561190cc5ba https://doi.org/10.1083/jcb.145.3.491

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UNC-60B, an ADF/Cofilin Family Protein, Is Required for Proper Assembly of Actin into Myofibrils in Caenorhabditis elegans Body Wall Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

UNC-60B, an ADF/Cofilin Family Protein, Is Required for Proper Assembly of Actin into Myofibrils in Caenorhabditis elegans Body Wall Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider