August 7, 2023Frontiers in PhysiologyOpen Access

Hemodynamic responses to handgrip and metaboreflex activation are exaggerated in individuals with metabolic syndrome independent of resting blood pressure, waist circumference, and fasting blood glucose

View Full Paper

Ask AI

Bookmark

Why the study?

Prior studies reported conflicting evidence regarding exercise pressor and metaboreflex responses in individuals with metabolic syndrome, and whether observed differences are explained by elevated resting blood pressure.

Does metabolic syndrome exaggerate hemodynamic responses to handgrip exercise and metaboreflex activation compared to matched controls?

Population

26 participants (13 with MetS)

Comparison

Individuals with MetS vs controls during handgrip exercise and PECO

Design

Physiological case-control study

Authors

JSJon StavresUniversity of Miami Health System RARyan A. AultmanUniversity of Southern Mississippi CBCaleb F. BrandnerUniversity of Iowa

Discussion

Member takes

Implication

Exaggerated responses may heighten exercise-related cardiovascular strain in MetS; leaves open prospective outcome links and intervention targets.

Structured PICO

Does metabolic syndrome exaggerate hemodynamic responses to handgrip exercise and metaboreflex activation compared to matched controls?

Population

26 participants (13 with metabolic syndrome [MetS], 13 matched controls). MetS defined by standard criteria (waist circumference, BP, FBG/HbA1c, HDL-C, TRG). Matched by age, biological sex, race, and ethnicity.

Intervention

2 minutes of isometric handgrip exercise (35% maximal voluntary contraction) followed by 3 minutes of post-exercise circulatory occlusion (PECO)

Comparator

Matched control subjects (≤2 cardiometabolic risk factors, not taking medications affecting cardiometabolic risk factors) undergoing the same handgrip and PECO protocol

Outcome

Hemodynamic responses including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and a cumulative blood pressure index (BPI) during handgrip exercise and PECOsurrogate

Individuals with metabolic syndrome exhibit exaggerated exercise pressor and metaboreflex responses independent of resting blood pressure, fasting blood glucose, or waist circumference, indicating altered cardiovascular reflex control.

Limitations

Small sample size for subgroup analysis (e.g., n=4 for non-hypertensive MetS group)

Cite This Study

Stavres et al. (2023) studied this question.

synapsesocial.com/papers/6a849fb2910603866be26e97 https://doi.org/10.3389/fphys.2023.1212775

View Full Paper

Ask AI

Bookmark

Implication

Exaggerated responses may heighten exercise-related cardiovascular strain in MetS; leaves open prospective outcome links and intervention targets.

Hemodynamic responses to handgrip and metaboreflex activation are exaggerated in individuals with metabolic syndrome independent of resting blood pressure, waist circumference, and fasting blood glucose

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Hemodynamic responses to handgrip and metaboreflex activation are exaggerated in individuals with metabolic syndrome independent of resting blood pressure, waist circumference, and fasting blood glucose

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider