Renal clearances during prolonged supine exercise at different loads

Clearance of inulin (CIn) and para-aminohippuric acid (CPAH), cardiac output, oxygen uptake, and arterial blood pressure were measured in 15 healthy male subjects at rest and during supine exercise of 45 min duration on a bicycle ergometer. Work loads between 150 and 900 kpm/min were chosen. CPAH decreased with increasing work intensity (heart rate). At an oxygen uptake corresponding to half of the aerobic work capacity it was about 70% and at heavy work 35–45% of the value at rest. The renal fraction of the cardiac output averaged, at rest, 17% and decreased with increasing work loads to 2.5–5% as a minimum. CIn did not change significantly until heavy exercise was performed. The filtration fraction increased during exercise. clearances of inulin and para-aminohippuric acid; cardiac output Submitted on May 28, 1965