What question did this study set out to answer?

To challenge the paradigm that G-protein-coupled receptors require dimerization or oligomerization for signal transduction by evaluating whether monomeric receptors function as autonomous units.

June 18, 2005Biochemistry

Monomeric G-Protein-Coupled Receptor as a Functional Unit

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Authors

MCMarc ChabreCentre National de la Recherche Scientifique MMMarc le MaireUniversité Paris-Sud

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Implication

Biochemical review demonstrates functional coupling of monomeric rhodopsin with heterotrimeric G proteins, suggesting single receptors drive signal transduction even within structural dimers.

Key Points

To challenge the paradigm that G-protein-coupled receptors require dimerization or oligomerization for signal transduction by evaluating whether monomeric receptors function as autonomous units.
Re-analyzed modern biochemical and biophysical data on detergent-solubilized rhodopsin and class 1a G-protein-coupled receptors.
Compared recent detergent-solubilization findings with classical foundational studies on membrane proteins.
Constructed a molecular structural model depicting the functional coupling between a single receptor monomer and a heterotrimeric G protein.
Modern detergent-solubilization experiments align with and strengthen classical literature demonstrating that rhodopsin and other class 1a receptors operate as functional monomers.
Structural molecular modeling confirmed that a single receptor monomer possesses the requisite interface to fully engage and functionally activate a G-protein heterotrimer, indicating that monomeric action persists even in receptors capable of structural dimerization.

Cite This Study

Chabre et al. (2005) studied this question.

synapsesocial.com/papers/6a84a130f27c451eb1bcc0fc https://doi.org/10.1021/bi050720o

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Implication

Biochemical review demonstrates functional coupling of monomeric rhodopsin with heterotrimeric G proteins, suggesting single receptors drive signal transduction even within structural dimers.

Monomeric G-Protein-Coupled Receptor as a Functional Unit

Discussion

Member takes

Implication

Key Points

Cite This Study

Monomeric G-Protein-Coupled Receptor as a Functional Unit

Discussion

Member takes

Implication

Key Points

Cite This Study

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