What question did this study set out to answer?

To determine whether the central actions of leptin on food intake and core body temperature are mediated by the cytokine interleukin-1.

June 8, 1999Proceedings of the National Academy of SciencesOpen Access

Leptin actions on food intake and body temperature are mediated by IL-1

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Authors

GLGiamal N. LuheshiDouglas Mental Health University Institute JGJason GardnerMcCann Associates (United States)DRDavid RushforthAllen Institute for Brain Science

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Implication

Experimental rodent study demonstrates interleukin-1-dependent appetite suppression and hyperthermia induced by leptin in rodents, indicating a key neuroimmune pathway in metabolic control.

Key Points

To determine whether the central actions of leptin on food intake and core body temperature are mediated by the cytokine interleukin-1.
Administered central (intracerebroventricular) or peripheral leptin to normal Sprague-Dawley rats, obese (fa/fa) Zucker rats, and IL-1 receptor type 1 knockout mice.
Measured changes in food intake, core body temperature, and hypothalamic IL-1beta levels following leptin treatment.
Assessed leptin-induced responses following pre-treatment with IL-1 receptor antagonist (IL-1ra) or a cyclooxygenase inhibitor.
Leptin induced dose-dependent hyperthermia and appetite suppression in normal rats while increasing hypothalamic IL-1beta, but had no effect in leptin-receptor-defective Zucker rats.
Central IL-1ra inhibited leptin-induced appetite suppression by 60% after central injection and 84% after peripheral injection, and completely abolished leptin-induced fever.
IL-1 receptor knockout mice displayed no leptin-induced reduction in food intake, and cyclooxygenase inhibition eliminated leptin-induced fever without affecting appetite suppression.

Cite This Study

Luheshi et al. (1999) studied this question.

synapsesocial.com/papers/6a84af2563149f2fb08e3bf8 https://doi.org/10.1073/pnas.96.12.7047

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Implication

Experimental rodent study demonstrates interleukin-1-dependent appetite suppression and hyperthermia induced by leptin in rodents, indicating a key neuroimmune pathway in metabolic control.

Leptin actions on food intake and body temperature are mediated by IL-1

Discussion

Member takes

Implication

Key Points

Cite This Study

Leptin actions on food intake and body temperature are mediated by IL-1

Discussion

Member takes

Implication

Key Points

Cite This Study

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