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January 23, 2010Current Opinion in Lipidology

Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events

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Why the study?

Do angiopoietin-like proteins regulate lipoprotein metabolism and affect cardiovascular events?

Population

Humans (population-based studies and patients with metabolic syndrome) and mice

Design

Review

Authors

TMTakashi MiidaJuntendo UniversitySHSatoshi HirayamaTokyo Gakugei University

Discussion

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Implication

May guide ANGPTL inhibitor development for hypertriglyceridemia; leaves open cardiovascular event reduction in trials.

Structured PICO

Do angiopoietin-like proteins regulate lipoprotein metabolism and affect cardiovascular events?

P
Population
Humans (population-based studies and patients with metabolic syndrome) and mice
I
Intervention
Angiopoietin-like proteins (Angptl3, Angptl4, Angptl5) concentrations and loss-of-function mutations
O
Outcome
Lipoprotein profiles (triglyceride and HDL-cholesterol concentrations) and cardiovascular disease/atherosclerosissurrogate

Angptl3, Angptl4, and Angptl5 are important regulators of lipoprotein metabolism, highlighting their potential as therapeutic targets for dyslipidemia and cardiovascular disease prevention.

Cite This Study

Miida et al. (2010) studied this question.

synapsesocial.com/papers/6a84b02c57e435c023a90da4https://doi.org/10.1097/mol.0b013e328333269e
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial lipase is a major determinant of HDL level2003 · 297 citations
  2. 2Serum Levels of Angiopoietin-Related Growth Factor Are Increased in Preeclampsia2008 · 23 citations
  3. 3Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function2009 · 144 citations
  4. 4Interaction of the coiled‐coil domain with glycosaminoglycans protects angiopoietin‐like 4 from proteolysis and regulates its antiangiogenic activity2008 · 100 citations
  5. 5Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids2009 · 206 citations