Highlights a rare presentation of complete heart block in an adult with SLE associated with anti-U1RNP antibodies rather than typical anti-SSA/Ro antibodies.
Anti-U1RNP may link to complete heart block in SLE despite negative anti-SSA/Ro; single case leaves open screening implications pending larger studies.
Report of a case of complete heart block in a patient with systemic lupus erythematosus (SLE). The cardiac disturbance presented as repeated syncopal episodes and normal cardiac clinical and electrocardiographic examination between these episodes. Circulating anti-U1RNP antibodies were detected and tests for anti-SSA/Ro, anti-SSB/La and antiphospholipid antibodies were negative. Evidence of myocarditis was not found. The diagnosis was just established when the patient developed a syncopal episode during hospitalization. Only one SLE case with a similar clinical course has been reported previously.
No takes yet. Share an insight, caveat, or question.
Fonseca et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: