Z only: An atom-economical synthetic route towards arylated Z-enamides through double CH functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B).
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Pankajakshan et al. (2012) studied this question.
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