Studies in the Sulphur Metabolism of the Dog

IN a former communication one of us [Hele, 1924, 1] was able to show that ethereal sulphates are formed by direct union of phenolic compounds with preformed sulphate. This work is directly opposed to the views held by Shiple, Muldoon and Sherwin [1924], who have published an account of work, which they interpret as evidence of the formation of ethereal sulphates from some product of endogenous sulphur metabolism, something of the type of a mercapturic acid being the intermediary. It seemed to us that perhaps this difference of opinion was caused by a difference in the species of animal employed, because, whereas dogs were used in this laboratory, a pig was used in the experiments of Shiple, Muldoon and Sherwin. We therefore decided to study the metabolism of the pig and to repeat as far as possible the experiments, which have been described in the former papers of this series and in which the dog was used as the experimental animal.