The association of MMP-13 rs2252070 with non-small cell lung cancer in the Turkish population

Aim: To evaluate the role of MMP-13 rs2252070 in patients with non-small cell lung cancer (NSCLC) in the Turkish population. Method: A total of 95 NSCLC patients and 94 healthy controls were included in this study. The MMP-13 rs2252070 variant was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The results of the analyses were evaluated for statistical significance. Results: There was no G/G homozygous genotype in the patient or control groups. The prevalence of genotypes of A/A and A/G profiles for the MMP-13 rs2252070 variant was 34.7% and 65.3%, respectively, in patients and 46.8% and 53.2%, respectively, in the control group. No significant difference was found between the patient and control groups in terms of MMP-13 rs2252070 genotype distribution and allele frequency (p= 0.091, OR: 0.605, CI 95%:0.337-1.086; p: 0.199, OR: 1.337, CI 95%: 0.858-2.083, respectively). Conclusions: Our results in this study showed no association between MMP-13 rs2252070 and NSCLC. To fully comprehend the mechanisms underlying NSCLC development, more research is required.