Population
In vitro platelets and in vivo stroke-prone spontaneously hypertensive rats
Comparison
Angiotensin II AT1 receptor antagonists vs Other AT1 receptor antagonists or control
Design
Review
Authors
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May indicate antiplatelet effects unique to losartan and irbesartan; leaves open impact on thrombotic outcomes.
Certain AT1 receptor antagonists like losartan and irbesartan possess additional antiplatelet effects via TXA2 receptor antagonism, which is independent of their AT1 receptor blockade.
López‐Farré et al. (2001) studied this question.
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