Why the study?
To evaluate lipid peroxidation and expression of the paraoxonase-1 (pon-1) gene in patients with preeclampsia.
Are serum MDA levels and PON-1 gene expression altered in patients with preeclampsia compared to normotensive pregnant women?
Are serum MDA levels and PON-1 gene expression altered in patients with preeclampsia compared to normotensive pregnant women?
Preeclampsia is associated with increased lipid peroxidation (elevated MDA) and decreased PON-1 gene expression, suggesting a role for oxidative stress in its pathogenesis.
Supports oxidative stress role in preeclampsia; hypothesis-generating for MDA/PON-1 as biomarkers, pending prospective validation.
Purpose: To evaluate lipid peroxidation and expression of paraoxonase-1 (pon-1) gene in patients with preeclampsia. Methodology: The study comprised of 160 participants, in which 80 were normotensive pregnant women (Group A) and 80 were preeclamptic pregnant women (Group B). Serum MDA levels and PON-1 gene activity were estimated. The expression of data was subjected to statistical analysis using SPSS version 20.0. One-way analysis of variance (ANOVA) was used to compare the test samples, p value <0.05 was considered significant. Findings: MDA levels were significantly elevated in preeclamptic pregnant women when compared to normotensive. Also, PON-1 gene expression levels were significantly decreased in preeclamptic pregnant women when compared to normotensive. Unique contribution to theory, practice and policy: The significant increase in the plasma level of Malondialdehyde and decreases expression of PON-1 gene could be responsible for the presence of oxidative stress and its associated complications in PE patients.
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Arobasalu et al. (2022) studied this question.
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