What question did this study set out to answer?

To determine which respiratory symptoms from the IUATLD Bronchial Symptoms Questionnaire predict bronchial reactivity to histamine in a general community sample.

January 1, 1989International Journal of Epidemiology

What Symptoms Predict the Bronchial Response to Histamine? Evaluation in a Community Survey of The Bronchial Symptoms Questionnaire (1984) of The International Union Against Tuberculosis and Lung Disease

View Full Paper

Ask AI

Bookmark

Authors

PBPeter BurneyUniversity of Southern California SCS ChinnBrigham and Women's Hospital JBJohn BrittonUniversity of Nottingham

Discussion

Member takes

Implication

Community survey demonstrates that a multi-symptom score predicts bronchial response to histamine in adults, indicating improved sensitivity over single-symptom questions like wheeze.

Key Points

To determine which respiratory symptoms from the IUATLD Bronchial Symptoms Questionnaire predict bronchial reactivity to histamine in a general community sample.
Surveyed adults aged 18–64 years from two areas of southern England using the 1984 IUATLD Bronchial Symptoms Questionnaire.
Conducted histamine challenge testing and analyzed symptom associations using a split-sample derivation and validation design.
Wheeze, waking with breathlessness, chest tightness from animals, dust, or feathers, and persistent breathing difficulty independently predicted histamine hyperreactivity in the derivation cohort.
A composite score based on these symptoms achieved higher sensitivity and comparable specificity for histamine reactivity in the validation cohort compared to asking about wheeze alone, whereas questions regarding asthma diagnoses were specific but lacked sensitivity.
Reported symptom patterns failed to distinguish bronchial reactivity associated with positive allergy skin tests from reactivity linked to cigarette smoking.

Cite This Study

Burney et al. (1989) studied this question.

synapsesocial.com/papers/6a84f599d19b8ef3405b5d2b https://doi.org/10.1093/ije/18.1.165

View Full Paper

Ask AI

Bookmark

Implication

Community survey demonstrates that a multi-symptom score predicts bronchial response to histamine in adults, indicating improved sensitivity over single-symptom questions like wheeze.

What Symptoms Predict the Bronchial Response to Histamine? Evaluation in a Community Survey of The Bronchial Symptoms Questionnaire (1984) of The International Union Against Tuberculosis and Lung Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

What Symptoms Predict the Bronchial Response to Histamine? Evaluation in a Community Survey of The Bronchial Symptoms Questionnaire (1984) of The International Union Against Tuberculosis and Lung Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider