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By ultracentrifligation at 90,000 × g, a particulate fraction inhibitory to growth of transplantable lymphosarcoma, Ehrlich ascites tumor and Yoshida sarcoma has been obtained from small intestines of mice and rats. 2. Inhibitory properties of the fraction have been demonstrated by pre-inoculation exposure of tumor cell suspensions to the inhibitory material. 3. The intestinal fraction markedly suppresses oxygen consumption of tumor slices, slightly reduces the respiration of normal lymphoid tissues, and has no effect on respiration of other normal tissues tested; an initial respiratory stimulation was observed with ascites tumor, followed by marked depression. 4. The active component of the intestinal fraction appears to be an ethanol and petroleum ether-soluble lipid.
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Bennett et al. (1953) studied this question.
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