Why the study?
Obesity is a significant risk factor for multiple chronic diseases, prompting a review focused on its related morbidities.
This review summarizes the extensive pathophysiological links between obesity and various systemic morbidities, including cardiovascular and metabolic diseases.
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May warrant obesity-focused CV risk assessment; leaves open prospective trials on targeted interventions.
Obesity is a significant risk factor for cardiovascular disorders, metabolic disorders, osteoarthritis, multiple cancers, serious mental illness, hypertension, dyslipidemia, diabetes mellitus and coronary artery disease. Obesity has been reported to promote oxidative stress, as obesity stimulates the penetration and activation of macrophages and monocytes into adipose tissue which, in turn, releases elevated levels of pro-inflammatory adipokines, such as tumour necrosis factor-alpha ( TNFa) and interleukin-6 (IL-6).Insulin resistance is associated with both type 2 diabetes and obesity. Alteration of lung mechanics in obese patients, including decreased lung capacities, decreased compliance, irregular breathing and perfusion and gas exchange, and respiratory muscle inefficiency, can predispose to increased risk and severity of respiratory infections. Obesity and atherosclerosis pathogenesis have many popular causes. In all cases, lipids, oxidized LDL particles and free fatty acids trigger the inflammatory response and induce the disease. In this review article, we have focused on different morbidities related to obesity.
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Butola et al. (2021) studied this question.
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