Why the study?
What is the relationship between obesity, oxidative stress, and mitochondrial impairment, and what are potential interventions to improve redox balance?
What is the relationship between obesity, oxidative stress, and mitochondrial impairment, and what are potential interventions to improve redox balance?
This review highlights the role of oxidative stress and mitochondrial impairment in obesity and its complications, suggesting that targeting redox balance may be a potential therapeutic strategy.
Oxidative imbalance may contribute to obesity-related cardiometabolic risk; leaves open whether redox-targeted therapies alter outcomes.
Obesity is a major risk factor for multiple severe health conditions, including cardiovascular diseases, diabetes and cancer. It is often related to an increased risk of morbidity and mortality and, as it can be accompanied by non-fatal health problems, quality of life is seriously reduced due to related conditions including hypertension, sleep apnea, osteoarthritis, respiratory problems and infertility. Evidence suggests that oxidative stress is related to obesity and its complications. In obese patients, there is an increase in levels of reactive oxygen species and nitrogen species and antioxidant defenses are undermined in comparison to normal-weight counterparts. In addition, these parameters inversely correlate with central adiposity. In this review, the authors discuss current concepts concerning the relationship between obesity and oxidative stress and mitochondrial impairment. Potential interventions to improve redox balance are also explored.
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Rovira‐Llopis et al. (2014) studied this question.
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