Why the study?
Does short-term and mild type 2 diabetes induce myocardial functional, structural, and molecular changes in Goto-Kakizaki rats compared to nondiabetic Wistar rats?
Population
Goto-Kakizaki (GK) rats, a non-obese model of type 2 diabetes mellitus (T2DM)
Comparison
Short-term and mild type 2 diabetes mellitus vs Age-matched nondiabetic Wistar rats
Design
Preclinical
Authors
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Hypothesis-generating for early diastolic changes in mild T2D; human studies needed before clinical relevance.
Does short-term and mild type 2 diabetes induce myocardial functional, structural, and molecular changes in Goto-Kakizaki rats compared to nondiabetic Wistar rats?
Short-term and mild type 2 diabetes in a non-obese rat model induces early diastolic dysfunction, myocardial fibrosis, and altered TNF-α expression before systolic dysfunction or electrical abnormalities occur.
Korkmaz‐Icöz et al. (2016) studied this question.
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