Population
Recombinant smooth muscle regulatory light chain expressed in Escherichia coli and introduced into myosin or…
Comparison
Mutant light chains vs Recombinant wild-type regulatory light chain
Design
Preclinical
Authors
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May guide myosin modulator development for vascular tone; leaves open clinical translation from animal biochemistry.
Activation of smooth muscle myosin requires the introduction of a negative charge in a specific spatial position, as demonstrated by mutagenesis of the phosphorylation site.
Kamisoyama et al. (1994) studied this question.
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