Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways
Population
Neonatal rat ventricular myocytes (in vitro) and adult rat hearts (in vivo)
Design
Preclinical
Authors
Discussion
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Implication
Resistin pathway effects in rodents do not inform patient care; leaves open therapeutic targeting in human diabetic cardiomyopathy.
Structured PICO
P
Population
Neonatal rat ventricular myocytes (in vitro) and adult rat hearts (in vivo)
I
Intervention
Overexpression of resistin using adenoviral vector
O
Outcome
Cardiac hypertrophy and myocardial insulin resistance signaling pathways (AMPK/mTOR and JNK/IRS1)surrogate
Resistin promotes cardiac hypertrophy and myocardial insulin resistance through the AMPK/mTOR and JNK/IRS1 signaling pathways, providing a potential mechanistic link between diabetes and heart failure.
Cite This Study
Kang et al. (2011) studied this question.