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March 19, 2022Cardiovascular Drugs and TherapyOpen Access

2-Arachidonoylglycerol Attenuates Myocardial Fibrosis in Diabetic Mice Via the TGF-β1/Smad Pathway

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Why the study?

Diabetic cardiomyopathy causes late cardiac dysfunction with myocardial fibrosis linked to TGF-beta1 up-regulation, and the protective effect of 2-arachidonoylglycerol on diabetic cardiomyopathy required evaluation.

Does 2-Arachidonoylglycerol reduce myocardial fibrosis and improve cardiac function in a diabetic mouse model?

Population

Male C57BL/6 mice after 12 weeks of diabetic modeling

Comparison

2-AG (10 micro g/kg/day intraperitoneally) vs control

Design

Animal experimental study

Follow-up

4 weeks

Authors

ZCZhengjie ChenLZLiangyu ZhengGCGang Chen

Discussion

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Member takes

Overview

May attenuate diabetic cardiomyopathy in models; leaves open clinical translation of 2-AG or TGF-β/Smad targeting.

Structured PICO

Does 2-Arachidonoylglycerol reduce myocardial fibrosis and improve cardiac function in a diabetic mouse model?

P
Population
Male C57BL/6 mice after 12 weeks of diabetic modeling
I
Intervention
2-Arachidonoylglycerol (2-AG) 10 micro g/kg/day injected intraperitoneally for 4 weeks
O
Outcome
Cardiac function (evaluated by echocardiography) and myocardial fibrosis (assessed by histology and western blot)surrogate

2-Arachidonoylglycerol attenuates myocardial fibrosis and improves cardiac function in diabetic mice by inhibiting the TGF-β1/Smad2/3 pathway.

Cite This Study

Chen et al. (2022) studied this question.

synapsesocial.com/papers/6a84f7a0de619cf7bcde0793https://doi.org/10.1007/s10557-021-07307-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aminoguanidine reduces diabetes‑associated cardiac fibrosis2019 · 21 citations
  2. 2Glucose-dependent insulinotropic polypeptide inhibits cardiac hypertrophy and fibrosis in diabetic mice via suppression of TGF-β22021 · 16 citations
  3. 3Chlorogenic Acid Alleviates Hyperglycemia‐Induced Cardiac Fibrosis through Activation of the NO/cGMP/PKG Pathway in Cardiac Fibroblasts2020 · 53 citations
  4. 4Inhibition of N-acetylglucosaminyltransferase V alleviates diabetic cardiomyopathy in mice by attenuating cardiac hypertrophy and fibrosis2024 · 2 citations
  5. 5Targeting TGF-β1/SMAD pathway and MMP-9 activity: the protective role of Vitamin D and Catechin in diabetic cardiomyopathy2026 · 1 citations