July 1, 1997Canadian Journal of Physiology and Pharmacology

Changes in electrophysiological and mechanical responses of the rat papillary muscle to α- and β-agonist in streptozotocin-induced diabetes

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Population

Streptozotocin-induced diabetic rats and age-matched controls

Comparison

Alpha 1-adrenoceptor agonist (methoxamine 10-10… vs Age-matched control rats

Design

Preclinical

Authors

KKKatsuo KamataHoshi University TST SatohKyorin University HTHirofumi TanakaPreventive Cardiology

Discussion

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Implication

Hypothesis-generating for alpha-adrenergic modulation in diabetic cardiomyopathy; leaves open any clinical relevance.

Structured PICO

Population

Streptozotocin (STZ)-induced diabetic rats and age-matched controls (depolarized right ventricular papillary muscle)

Intervention

Alpha 1-adrenoceptor agonist (methoxamine 10(-7)-10(-4) M) and beta-adrenoceptor agonist (isoproterenol 10(-9)-10(-6) M)

Comparator

Age-matched control rats

Outcome

Electrophysiological and mechanical responses (slow response action potential amplitude, APD50, and contraction)surrogate

In diabetic rats, alpha-adrenoceptor-mediated electrophysiological responses in the myocardium are unmasked as beta-adrenoceptor-mediated responses become desensitized.

Cite This Study

Kamata et al. (1997) studied this question.

synapsesocial.com/papers/6a84f7dbe7eca461fe847672 https://doi.org/10.1139/y97-095

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Changes in electrophysiological and mechanical responses of the rat papillary muscle to α- and β-agonist in streptozotocin-induced diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Changes in electrophysiological and mechanical responses of the rat papillary muscle to α- and β-agonist in streptozotocin-induced diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider