April 20, 2010Journal of Cellular Biochemistry

Molecular approaches to examine the phosphorylation state of the C type natriuretic peptide receptor

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Population

Recombinant GST-NPRC fusion protein and rat gastric mucosa (RGM1) cell line

Design

Preclinical

Authors

AAAbdel A. AlliUniversity of Florida WGWilliam R. GowerUniversity of South Florida

Discussion

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Implication

Enables targeted studies of NPRC regulation; leaves open the functional role of Thr 505 phosphorylation in vivo.

Structured PICO

Population

Recombinant GST-NPRC fusion protein and rat gastric mucosa (RGM1) cell line

Intervention

Molecular tools including recombinant GST fusion protein, RGM1 cell line, and phosphospecific antibodies to study phosphorylation state

Outcome

Phosphorylation state of the C type natriuretic peptide receptor (NPRC) and identification of specific phosphorylated residues and kinasessurrogate

This basic science study provides molecular tools to examine NPRC phosphorylation and identifies Thr 505 as a likely candidate site for PKA-mediated phosphorylation.

Cite This Study

Alli et al. (2010) studied this question.

synapsesocial.com/papers/6a84f7de39db847d1cde075a https://doi.org/10.1002/jcb.22612

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Molecular approaches to examine the phosphorylation state of the C type natriuretic peptide receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular approaches to examine the phosphorylation state of the C type natriuretic peptide receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider