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Does PDK1 inhibition reduce vasoconstrictor-induced contraction in the carotid arteries of a type 2 diabetic rat model?
Does PDK1 inhibition reduce vasoconstrictor-induced contraction in the carotid arteries of a type 2 diabetic rat model?
PDK1 contributes to increased serotonin-induced contraction in the carotid arteries of a type 2 diabetic rat model, suggesting a potential target for diabetic vascular complications.
PDK1 inhibition attenuates diabetic carotid hyperreactivity in rats; hypothesis-generating for human vascular complications.
mimetic (U46619) in the presence of nitric oxide synthase inhibitor in the carotid arteries of Goto-Kakizaki (GK) rats, a spontaneous type 2 diabetic model, in the chronic stage of disease. Serotonin-induced contraction was greater in the GK rats than in the control Wistar rats. A specific PDK1 inhibitor (GSK2334470) decreased the serotonin-induced contraction in the GK rats but not in the Wistar rats, and the difference in such contraction was abolished with this treatment. In GK rats, phenylephrine-induced contraction exhibited a leftward shift and U46619-induced contraction was greater still. Phenylephrine- and U46619-induced contractions were reduced by GSK2334470 in both groups. These results suggest, for the first time, that the contribution of PDK1 is different among 3 vasoconstrictors and that PDK1 contributed to increased serotonin-induced contraction in the carotid arteries of GK rats.
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Watanabe et al. (2017) studied this question.
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