What question did this study set out to answer?

To determine whether serum angiotensin-converting enzyme (SACE) levels exhibit diurnal fluctuation or acute changes following high-dose corticosteroid administration, and to evaluate prednisolone pharmacokinetics in patients with sarcoidosis.

November 1, 1986American Review of Respiratory Disease

Angiotensin-Converting Enzyme

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Authors

PTPhilip J. ThompsonHollywood Private Hospital MKMichael KempUniversity of Copenhagen WMW A McAllisterMedical University of South Carolina

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Implication

Placebo-controlled crossover trial reveals minimal diurnal variation and no acute corticosteroid effect on serum angiotensin-converting enzyme in sarcoidosis, indicating stable biomarker monitoring.

Key Points

To determine whether serum angiotensin-converting enzyme (SACE) levels exhibit diurnal fluctuation or acute changes following high-dose corticosteroid administration, and to evaluate prednisolone pharmacokinetics in patients with sarcoidosis.
Evaluated 10 patients with histologically proven sarcoidosis across two consecutive 24-hour monitoring periods.
Collected serial blood samples for 24 hours following placebo on Day 1 and following 75 mg of oral prednisolone at identical time points on Day 2.
Measured prednisolone pharmacokinetics in 8 of the participants for comparison with historical data from normal volunteers.
Showed no discernible diurnal variation in SACE levels on either day and no significant acute difference following 75 mg of oral prednisolone.
Identified a mean maximal difference of 8.8% within or between days, establishing that SACE shifts exceeding 9% likely reflect genuine biological change rather than normal variation.
Found prednisolone pharmacokinetics in sarcoidosis patients to be comparable to parameters observed in healthy volunteers.

Cite This Study

Thompson et al. (1986) studied this question.

synapsesocial.com/papers/6a84f89d5d33534bf2de0653 https://doi.org/10.1164/arrd.1986.134.5.1075

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Implication

Placebo-controlled crossover trial reveals minimal diurnal variation and no acute corticosteroid effect on serum angiotensin-converting enzyme in sarcoidosis, indicating stable biomarker monitoring.

Angiotensin-Converting Enzyme

Discussion

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Implication

Key Points

Cite This Study

Angiotensin-Converting Enzyme

Discussion

Member takes

Implication

Key Points

Cite This Study

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