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January 1, 2015Evidence-based Complementary and Alternative MedicineOpen Access

Total Flavonoids fromClinopodium chinense(Benth.) O. Ktze Protect against Doxorubicin-Induced CardiotoxicityIn VitroandIn Vivo

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Why the study?

Does TFCC pretreatment prevent doxorubicin-induced cardiotoxicity in preclinical models?

Population

Male rats and H9C2 cardiomyocytes

Comparison

Total flavonoids from Clinopodium chinense O… vs Doxorubicin alone and/or vehicle control

Design

Preclinical

Follow-up

2 weeks after the last DOX dose (in vivo)

Authors

RCRong Chang ChenXXXu Dong XuXLXue Zhi Liu

Discussion

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Overview

May support TFCC development for doxorubicin cardiotoxicity prevention; leaves open clinical translation pending human trials.

Structured PICO

Does TFCC pretreatment prevent doxorubicin-induced cardiotoxicity in preclinical models?

P
Population
Male rats and H9C2 cardiomyocytes
I
Intervention
Total flavonoids from Clinopodium chinense (Benth.) O. Ktze (TFCC) pretreatment
C
Comparator
Doxorubicin alone (3 mg/kg every 2 days for three injections in rats) and/or vehicle control
O
Outcome
Cardiotoxicity (cardiac tissue injury, oxidative stress, apoptotic damage, mitochondrial dysfunction, cell viability)surrogate

TFCC shows potential in preventing doxorubicin-induced cardiotoxicity through modulation of apoptotic and survival signaling pathways in preclinical models.

Cite This Study

Chen et al. (2015) studied this question.

synapsesocial.com/papers/6a84f8bcde619cf7bcde080dhttps://doi.org/10.1155/2015/472565
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  3. 3The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.1997 · 1,089 citations