August 3, 2018Proceedings of the National Academy of Sciences

Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels

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Population

HCN channels

Design

Preclinical

Authors

GFGalen E. FlynnUniversity of Washington WZWilliam N. ZagottaElectrophysiology

Discussion

Member takes

Implication

Challenges conventional HCN gating models in animals; leaves open relevance to human pacemaker function and therapies.

Structured PICO

Population

HCN channels

Intervention

Investigation of the role of the S4-S5 linker and voltage-sensing domain in channel gating

Outcome

Molecular mechanism of hyperpolarization-dependent activation

This study provides a novel mechanistic model for HCN channel activation, showing it relies on the relief of autoinhibition rather than the S4-S5 linker.

Cite This Study

Flynn et al. (2018) studied this question.

synapsesocial.com/papers/6a84fc69412f1be49af118d5 https://doi.org/10.1073/pnas.1805596115

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Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider