Why the study?
Recent randomized trial data rekindled interest in using angiotensin in shock, prompting an outline of its physiology, clinical uses, and wider critical care potential.
This review outlines the renin-angiotensin system and the proposed clinical uses of angiotensin II, particularly in shock and critical care.
May support adjunctive angiotensin II in refractory shock; leaves open need for randomized efficacy trials.
Interest in the use of angiotensin (AT) (particularly in the context of shock) had been rekindled by recent randomized trial data (notably the AT II for the Treatment of High-Output Shock-3 study). This review article outlines the renin–AT system in health and during sepsis as well as the proposed clinical uses of AT II. The potential for wider application within critical care is also considered.
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Ahmadnia et al. (2019) studied this question.
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