In an effort to further our knowledge of the relationship between the chemical constitution and physiologic action of compounds related to epinephrine and ephedrine, as well as to establish the possible therapeutic uses of phenylaminoethanol sulphate we have continued our investigation of this substance. The first report on the clinical study of this substance from our laboratory¹showed that its local application in the nose caused marked shrinking and paling of the mucous membrane without the irritation so frequently found when epinephrine is used. The duration and intensity of the local effect were in every way comparable to that of ephedrine. Phenylaminoethanol sulphate differs from ephedrine, however, in that it appears to be without useful therapeutic effect on the bronchi when injected subcutaneously or when taken orally. Topical application in the nose for the shrinking of swollen membranes thus appeared to be a clinically useful effect of phenylaminoethynol sulphate.
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George Piness (1930) studied this question.