Invasiveness of Salmonella Typhimurium in HEp‐2 Cell Cultures Pretreated With Uv‐Inactivated Coxsackie Virus

The invasiveness of Salmonella typhimurium was significantly enhanced in cell cultures pretreated with UV-inactivated virus. During the first 3 hours of virus infection there was no difference between the enhancement achieved with non-inactivated and that achieved with UV-inactivated virus. After 4 and 5 hours pretreatment the effect of non-inactivated virus was more pronounced than that of UV-inactivated virus. The results indicate that during the early period of virus infection the enhancement of bacterial invasiveness by pretreatment with virus is the result of a direct interaction between the virus and the cell membrane. During the later phase of viral reproduction, viral RNA induced alteration of the cell metabolism, and these altered products might be involved in the interaction.