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In adult domestic rabbits inoculated with Shope fibroma virus, tumors began to regress about the 9th day. Well-defined, delayed-type hypersensitivity reactions following intradermal challenge with virus antigen developed on the 5th day, but circulating antibody was not demonstrable before the 7th day. Second injections of virus produced tumors up to the 4th day but not later. Rabbits inoculated with virus shortly after birth had progressively growing tumors. Circulating antibody was demonstrable in the newborns on the 7th or 8th day, but no delayed-type reaction could be elicited, even by passive transfer of lymph node cells into the skins of adult rabbits carrying fibromas. From these results and experiments with immunosuppressants it is concluded that the main Factor involved in the regression of the fibroma is the cellular immune response, and that the failure of this response can account For the progressive growth of fibromas in newborns.
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A. C. Allison (1966) studied this question.
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