Why the study?
Does injection of lymphokine-rich supernatants induce synovitis in normal rabbit knee joints?
Population
Rabbits with antigen-induced experimental arthritis, human rheumatoid synovial fluids, and normal rabbit…
Design
Preclinical
Authors
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Lymphokine supernatants induce experimental synovitis; leaves open whether these mediators drive human chronic arthritis and warrants clinical investigation.
Does injection of lymphokine-rich supernatants induce synovitis in normal rabbit knee joints?
Soluble factors of the lymphokine variety likely mediate some of the pathological changes observed in active chronic synovitis.
Rosenthal et al. (1975) studied this question.
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