TUMOR, rubor, calor et dolor, cum functione laesa: since the times of the ancients these have been the cardinal signs of inflammation, diagnostic of a reaction by the organism that was detrimental to its well-being. In 1883, Rudolph Virchow, the founder of cellular pathology, advised Metchnikoff to proceed with his researches cautiously, since "most pathologists do not believe in the protective role of inflammation."1 Metchnikoff proceeded, although not with caution, and his life's work provided the basis for the recognition that cellular as well as humoral mechanisms participate in immunity and immunopathology. There is now substantial evidence that cellular . . .
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Balko et al. (1973) studied this question.
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