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Adult Lewis rats were thymectomized, irradiated (900 r), and given bone marrow cells from normal (BN × Lewis) F 1 donors. Passive transfer of adjuvant arthritis was carried out with lymph node cells of Lewis donors sensitized 9 days earlier. The recipients showed clinical arthritis starting at 3‐8 days and were sacrificed at 9‐13 days. Live cell suspensions from affected joints and lymphoid tissues were assayed for F 1 marrow‐derived cells by an indirect fluorescence technic. The results suggest that a majority of cells in the joint lesions of adjuvant arthritis are hematogenous and derived from bone marrow precursors.
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Putnam et al. (1969) studied this question.
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