What question did this study set out to answer?

To review existing models of polygenic traits and advocate for an integrated framework combining quantitative genetics, population genetics, and systems biology to study local adaptation.

April 21, 2021Trends in GeneticsOpen Access

Polygenic Adaptation: Integrating Population Genetics and Gene Regulatory Networks

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To review existing models of polygenic traits and advocate for an integrated framework combining quantitative genetics, population genetics, and systems biology to study local adaptation.
Synthesized theoretical models from quantitative genetics and population genetics assessing the genetic architecture of polygenic traits and responses to directional selection.
Evaluated systems biology approaches that investigate the molecular bases and evolution of gene regulatory networks underlying complex traits.
Traditional quantitative and population genetics models effectively describe phenotypic trajectories under directional selection but lack resolution regarding underlying molecular mechanisms.
Systems biology provides key insights into how gene regulatory networks coordinate the expression and evolution of polygenic traits.
Constructing a unified framework that merges network biology with population genetics is necessary to resolve the molecular architecture of polygenic adaptation.

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Implication

Conceptual review demonstrates the role of gene regulatory networks in polygenic adaptation, highlighting the need to integrate systems biology with quantitative genetics.

Cite This Study

Fagny et al. (2021) studied this question.

synapsesocial.com/papers/6a850436b7cd3c76619deb16 https://doi.org/10.1016/j.tig.2021.03.005

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Implication

Conceptual review demonstrates the role of gene regulatory networks in polygenic adaptation, highlighting the need to integrate systems biology with quantitative genetics.

Polygenic Adaptation: Integrating Population Genetics and Gene Regulatory Networks

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Discussion

Implication

Cite This Study

Polygenic Adaptation: Integrating Population Genetics and Gene Regulatory Networks

Key Points

Discussion

Implication

Cite This Study

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