February 1, 1996Molecular Biology of the CellOpen Access

Identification of a cyclase-associated protein (CAP) homologue in Dictyostelium discoideum and characterization of its interaction with actin.

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Population

Dictyostelium discoideum cells and Escherichia coli (for protein expression)

Design

Preclinical

Authors

UGUlrich GottwaldBayer (Germany)RBRegine BrokampUniversity of Cologne IKIakowos KarakesisoglouDurham University

Discussion

Member takes

Implication

Supports PIP2-regulated actin sequestration by CAP in Dictyostelium; leaves open its role in mammalian cardiovascular cytoskeletal dynamics.

Structured PICO

Population

Dictyostelium discoideum cells and Escherichia coli (for protein expression)

Intervention

Expression of complete cyclase-associated protein (CAP) and its amino-terminal and carboxyl-terminal domains

Outcome

Interaction of Dictyostelium CAP with actin (actin binding, sequestering, fluorescence enhancement, polymerization, viscometric assays)surrogate

Dictyostelium discoideum CAP interacts with actin and is involved in microfilament reorganization near the plasma membrane in a PIP2-regulated manner.

Cite This Study

Gottwald et al. (1996) studied this question.

synapsesocial.com/papers/6a850465abaf849ca59defaf https://doi.org/10.1091/mbc.7.2.261

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Implication

Supports PIP2-regulated actin sequestration by CAP in Dictyostelium; leaves open its role in mammalian cardiovascular cytoskeletal dynamics.

Identification of a cyclase-associated protein (CAP) homologue in Dictyostelium discoideum and characterization of its interaction with actin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of a cyclase-associated protein (CAP) homologue in Dictyostelium discoideum and characterization of its interaction with actin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider