Why the study?
Patients with left-sided breast cancer receiving radiotherapy are at risk of chronic cardiac toxicities, which can be reduced by cardiac dose-sparing techniques such as deep-inspiration breath-hold.
A newly developed model incorporating anatomical and clinical factors may help guide the use of deep-inspiration breath-hold to reduce cardiac toxicity in patients undergoing radiotherapy for left-sided breast cancer.
May guide DIBH selection in left breast RT; leaves open prospective validation before clinical adoption.
Patients with left-sided breast cancer receiving radiotherapy are at risk of developing chronic cardiac toxicities. Cardiac dose-sparing techniques such as deep-inspiration breath-hold (DIBH) can reduce this risk. In this study, a model has been developed including tumor localization, left lung volume, and the distance between the heart and medial chest wall as well as age and Eastern Cooperative Oncology Group (ECOG) performance status, which may help to guide the decision for or against DIBH after planning computed tomography (CT) in free breathing directly before initiation of radiotherapy planning.
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Linge et al. (2025) studied this question.
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