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September 15, 2020ACS CatalysisOpen Access

N-Acylethanolamine Acid Amidase (NAAA): Mechanism of Palmitoylethanolamide Hydrolysis Revealed by Mechanistic Simulations

Laura Scalvini Andrea Ghidini Alessio Lodola Donatella Callegari Silvia Rivara Daniele Piomelli Marco Mor

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Abstract

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The N-terminal cysteine hydrolase N-acylethanolamine acid amidase (NAAA) catalyzes the hydrolytic deactivation of the lipid messenger, palmitoylethanolamide (PEA), with optimal activity at acidic p...

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Scalvini et al. (2020) studied this question.

synapsesocial.com/papers/6a850906ca95d8503fe58f6b https://doi.org/10.1021/acscatal.0c02903

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