Regulatory Mechanisms in the Synthesis of Enzymes of Galactose Metabolism: Part II. Genetic Defects in Galactokinase Activity and Their Relations to Its Functions

It was observed a few years ago (Kalckar, Kurahashi, and Jordan, 1959) that the defects in the gene for galactokinase, i.e., K defects, coincided with an unrepressed synthesis of transferase (T). This lack of repression was later shown to include the synthesis of epimerase (E) (Nikaido and Fukasawa, 1961; Jordan, Yarmolinsky, and Kalckar, 1961).