This is Chapter 10 of the book Exploiting Chemical Diversity for Drug Discovery which forms part of the RSC Biomolecular Sciences series. More information about this book and the whole series is available from www.rsc.org/biomolecularsciences or the RSC Sales team (sales@rsc.org).
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Eric Trinquet (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: