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July 1, 1989Journal of Applied Physiology

Effect of beta-adrenoceptor blockade on renin-aldosterone and alpha-ANF during exercise at altitude

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Why the study?

Does pindolol alter the renin-aldosterone system and alpha-ANF responses during exercise at high altitude?

Population

12 subjects

Comparison

Pindolol 15 mg/day during maximal bicycle… vs Maximal bicycle ergometer exercise without…

Design

Other

Follow-up

5 days

Authors

PBP. BouissouInsermJRJean‐Paul RichaletCross-Cutting CardiologyFGF. X. GalenCentre National de la Recherche Scientifique

Discussion

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Implication

Beta-blockade may not further suppress aldosterone at altitude; leaves open non-beta mechanisms for hypoxic renin inhibition.

Structured PICO

Does pindolol alter the renin-aldosterone system and alpha-ANF responses during exercise at high altitude?

P
Population
12 subjects
I
Intervention
Pindolol 15 mg/day (nonselective beta-blocker) during maximal bicycle ergometer exercise at sea level and during a 5-day period at high altitude (4,350 m)
C
Comparator
Maximal bicycle ergometer exercise without pindolol treatment at sea level and high altitude
O
Outcome
Hormonal responses to hypoxia including plasma renin activity, plasma alpha-atrial natriuretic factor (alpha-ANF), and plasma aldosterone concentrationsurrogate

Beta-adrenergic mechanisms do not appear to be responsible for the inhibition of renin secretion observed at high altitude.

Cite This Study

Bouissou et al. (1989) studied this question.

synapsesocial.com/papers/6a85101c3b4191c9949eaac7https://doi.org/10.1152/jappl.1989.67.1.141
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